Author Topic: What are you buying today?  (Read 1655231 times)

Gregmal

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Re: What are you buying today?
« Reply #4620 on: February 20, 2020, 04:00:11 PM »
Yea CRISPR will/is changing everything. There are so many offshoot and modifications from the base technology that its quite incredible. I have a few friends in grad programs at some of the top biomedical engineering programs and everyone says the same thing; that CRISPR is now the foundation for pretty much every application they study. Finding areas to invest is hard though. IP is somewhat vague. The companies working on it trade on potential revenue thats like half a decade or more out, at best...and nothing is even remotely cheap. BEAM Therapuetics I like as well, but its in the same boat.

My first instinct with stuff like this that is relatively new (at least new to being commercialized in any significant way) is that there are likely to be better mousetraps built over time.

Based on what you know is this kind of software the kind of thing that would have network effects, where one researcher in CA thinks hey I found something promising so I'm going to send it to my buddy in Boston, and they'll need the same software to be able to see the same things? That would be great. I wonder if these softwares won't end up being part of a menu of choices to find new drugs. What I mean is Schrodinger says they their recommendations are physics-based. Maybe that type of software views the world of drug candidates a certain way. Then another type of CRISPR software with some other foundation might be better suited for other applications.

From what I read, Schrodinger believed their software was better than others because their software can analyze all potential physical relationships between atoms, even ones that haven't ever been tested. The other CRISPR softwares are more based on actual attempted molecules by other scientists, so they kind of function like machine learning where the more molecules that are input into the software by other scientists the more the software "knows".

This probably sounds like gibberish, and it probably is, but its a fascinating area of research/business. The idea that biotech could become a lot more like any other type of manufacturing has profound implications for the pace of drug discovery and ultimately the cost to bring drugs to market, which could reduce the prices of previously very expensive treatments.  There was a great Andreesseen Horowitz presentation on this a couple months ago.

The CRISPR application stuff is crazy complex and has shoot offs that make it very difficult to really determine "ownership" per say, which is different than an AI based software application. When you integrate aspects of the two though, you probably have something pretty remarkable, or at least capable of being pretty remarkable; although a lot of that is out of my universe in terms of understanding it. So yes, theoretically you could have some AI programs running simulations and algorithms to narrow down the field of combinations that ultimately leads to, say, a CRISPR pill capable of knocking out one's susceptibility to the flu...or (substitute pretty much anything). I feel the programming and software element is actually a little easier to track because its more defined and ownership is clear. Whereas the CRISPR applications you are seeing in labs, have many different intricacies to them and will undoubtedly continue to evolve. First, you had the Cas9 which then had sub approaches. Then you had the whole cpf1 approach widely deemed to be better due to improved precision. Not long after the c2c(x) developments. And so on.

Its largely the same names doing a lot of the heavy lifting here, and as some have pointed out, its hard to really pin down how, say "Editas" will be the one who makes money from this 10 years from now, but its a game changing development and those with associations to it should reap the benefits, especially in a decent market.



Spekulatius

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Re: What are you buying today?
« Reply #4621 on: February 20, 2020, 04:02:55 PM »
Schrodingers software helps with drug discovery, but I don’t think it has any impact on the time consuming clinical trials Phase I-3 where the real money is spent. CRISP at this point is ay an early stage and we do not know how effective that approach will be. Any treatment likely is at least 5 years off.

It is likely that there will be opportunities where the hype cools off and those type of stocks can be acquired way cheaper, but who knows.
Life is too short for cheap beer and wine.

boilermaker75

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Re: What are you buying today?
« Reply #4622 on: February 21, 2020, 10:12:38 AM »
Wrote BRKB 225-strike, Feb 28-expiration puts.

boilermaker75

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Re: What are you buying today?
« Reply #4623 on: February 21, 2020, 11:07:21 AM »
Wrote BRKB 225-strike, Feb 28-expiration puts.

Wrote some more puts, 215-strike, Feb 28-expiration.

Gregmal

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Re: What are you buying today?
« Reply #4624 on: February 21, 2020, 11:37:48 AM »
little more MSGN under 14. can thank all these legacy turds like Viacom for continuing to create reasons for people to sell anything in this space into oblivion.

John Hjorth

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Re: What are you buying today?
« Reply #4625 on: February 21, 2020, 01:05:09 PM »
Wrote BRKB 225-strike, Feb 28-expiration puts.
Wrote some more puts, 215-strike, Feb 28-expiration.

Every time I read about Mike [CoBF member boilermaker] doing this stuff, I get hit - in a mild way - by a brain hemorrhage [Because I can't do stuff like this, for Danish tax and other regulatory reasons for Danish investors].

Today, two times! *sigh*
”In the race of excellence … there is no finish line.”
-HH Sheikh Mohammed Bin Rashid Al Maktoum, Vice President and Prime Minister of the United Arab Emirates and Ruler of Dubai

rb

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Re: What are you buying today?
« Reply #4626 on: February 21, 2020, 01:13:05 PM »
Wrote BRKB 225-strike, Feb 28-expiration puts.
Wrote some more puts, 215-strike, Feb 28-expiration.

Every time I read about Mike [CoBF member boilermaker] doing this stuff, I get hit - in a mild way - by a brain hemorrhage [Because I can't do stuff like this, for Danish tax and other regulatory reasons for Danish investors].

Today, two times! *sigh*
There are ways around that.

John Hjorth

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Re: What are you buying today?
« Reply #4627 on: February 21, 2020, 01:28:17 PM »
Wrote BRKB 225-strike, Feb 28-expiration puts.
Wrote some more puts, 215-strike, Feb 28-expiration.

Every time I read about Mike [CoBF member boilermaker] doing this stuff, I get hit - in a mild way - by a brain hemorrhage [Because I can't do stuff like this, for Danish tax and other regulatory reasons for Danish investors].

Today, two times! *sigh*
There are ways around that.

Well, I actually agree on that. It's about moving your own butt, - to get subject to another tax system. Last time I vented something like this, I got a reply from wachtwoord here on CoBF : "Why don't you just move?" [-or something like that, - now years ago]. Perhaps just time shut up here for me.
”In the race of excellence … there is no finish line.”
-HH Sheikh Mohammed Bin Rashid Al Maktoum, Vice President and Prime Minister of the United Arab Emirates and Ruler of Dubai

Castanza

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Re: What are you buying today?
« Reply #4628 on: February 21, 2020, 01:28:33 PM »
Wrote BRKB 225-strike, Feb 28-expiration puts.
Wrote some more puts, 215-strike, Feb 28-expiration.

Every time I read about Mike [CoBF member boilermaker] doing this stuff, I get hit - in a mild way - by a brain hemorrhage [Because I can't do stuff like this, for Danish tax and other regulatory reasons for Danish investors].

Today, two times! *sigh*

That's interesting. I've been discussing taxes with some coworkers from Prague and it's fascinating to see the differences between the US and there. Their opinions of tax codes are even better  :P

gjangal

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Re: What are you buying today?
« Reply #4629 on: February 24, 2020, 05:38:44 AM »
Planning to add DDOG during this correction